clinDR: Simulation and Analysis Tools for Clinical Dose Response Modeling

Bayesian and ML Emax model fitting, graphics and simulation for clinical dose response. The summary data from the dose response meta-analyses in Thomas, Sweeney, and Somayaji (2014) <doi:10.1080/19466315.2014.924876> and Thomas and Roy (2016) <doi:10.1080/19466315.2016.1256229> Wu, Banerjee, Jin, Menon, Martin, and Heatherington(2017) <doi:10.1177/0962280216684528> are included in the package. The prior distributions for the Bayesian analyses default to the posterior predictive distributions derived from these references.

Version:	2.5.3
Depends:	R (≥ 3.5.0), rstan (≥ 2.17.3), shiny
Imports:	foreach, graphics, DoseFinding, stats, mvtnorm, utils, parallel, doParallel, ggplot2, tidyr, purrr, tibble, dplyr, glue, waiter, officer
Suggests:	knitr, rmarkdown
Published:	2026-09-21
DOI:	10.32614/CRAN.package.clinDR
Author:	Neal Thomas [aut, cre], Jing Wu [aut], Mike K. Smith [aut], Budhaditya Goswami [aut], Satrajit Roychoudhury [aut]
Maintainer:	Neal Thomas <snthomas99 at gmail.com>
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation:	no
Materials:	NEWS
In views:	Pharmacokinetics
CRAN checks:	clinDR results

Documentation:

Reference manual:	clinDR.html , clinDR.pdf
Vignettes:	"Example of Bayesian Emax dose response modeling" (source) "Getting started with clinDR" (source) "Using a Mixture Prior for E0 in the Bayesian Emax Model" (source)

Downloads:

Package source:	clinDR_2.5.3.tar.gz
Windows binaries:	r-devel: clinDR_2.5.2.zip, r-release: clinDR_2.5.2.zip, r-oldrel: clinDR_2.5.2.zip
macOS binaries:	r-release (arm64): clinDR_2.5.3.tgz, r-oldrel (arm64): clinDR_2.5.3.tgz, r-release (x86_64): clinDR_2.5.3.tgz, r-oldrel (x86_64): clinDR_2.5.3.tgz
Old sources:	clinDR archive

Reverse dependencies:

Reverse depends:	ememax
Reverse suggests:	BayesianMCPMod

Linking:

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